Melanoma is a form of skin cancer that can be successfully managed in the outpatient setting at early stages, but becomes increasingly deadly as the stage of diagnosis increases. Treatment options include targeted therapy and immunotherapy combinations. Checkpoint inhibitors are standard of care for patients without targetable mutations, while patients with BRAF mutations may also receive BRAF/MEK combos. Immuno-oncology agents and novel therapy combinations are likely to emerge as future options and there remains an unmet need for effective treatments following progression on systemic therapy.
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